Uncategorized

A platform for artificial intelligence based identification of the extravasation potential of cancer cells into the brain metastatic niche

C. Ryan Oliver, Megan A. Altemus, Trisha M. Westerhof, Hannah Cheriyan, Xu Cheng, Michelle Dziubinski, Zhifen Wu, Joel Yates, Aki Morikawa, Jason Heth, Maria G. Castro, Brendan M. Leung, Shuichi Takayama, Sofia D. Merajver. A platform for artificial intelligence based identification of the extravasation potential of cancer cells into the brain metastatic niche. (2019) LAB ON A CHIP 2019. [DOI: 10.1039/C8LC01387J ]

Brain metastases are the most lethal complication of advanced cancer; therefore, it is critical to identify when a tumor has the potential to metastasize to the brain.  There are currently no interventions that shed light on the […]

University of Michigan Cancer Center Symposium 2017

We will be presenting work about a blood brain niche on a chip that have developed to understand clonal variation in breast cancer cells that metastasis to the brain.  This is a great event to meet a variety of cancer researchers and understand how biology, materials and microfluidics can be leveraged to solve translational problems.

Metastasis from the primary tumor site to the brain is the most lethal complication of advanced cancer.  15% of breast cancers metastasize in the brain with a median survival of 5-14 months depending on the subtype.  Therefore, it is critical to identify when a tumor has […]

ON-DEMAND ISOLATION AND MANIPULATION OF C. ELEGANS BY IN VITRO MASKLESS PHOTOPATTERNING.

C.R. Oliver, E. Gourgou, D. Bazopoulou, N. Chronis, A. John Hart. On-demand isolation and manipulation of C. elegans by in vitro maskless photopatterning. PLOS One 2016. doi: 10.1371/journal.pone.0145935

Caenorhabditis elegans (C. elegans) is a model organism for understanding aging and studying animal behavior. Microfluidic assay techniques have brought widespread advances in C.elegans research; however, traditional microfluidic assays such as those based on soft lithography require time-consuming design and fabrication cycles and offer limited flexibility in changing the geometric environment during experimentation. We present a technique for maskless photopatterning of a biocompatible hydrogel on an NGM (Agar) substrate, enabling dynamic manipulation of […]

Discrete Object Additive Manufacturing (DOAM): Digital Three-Dimensional Printing of Cells and Microbeads within Hydrogel Matrices

At the Materials Research Society (MRS) annual meeting (2015) I will be presenting my work titled: Discrete Object Additive Manufacturing (DOAM): Digital Three-Dimensional Printing of Cells and Microbeads within Hydrogel Matrices  

Authors: C. R. Oliver, A. J. Hart,

Symposium: C3.09

Location: Hynes Level 3, Room 305

Time: Dec 1 (Tuesday): 11:30 AM to 11:45 AM

 

I hope to see you there and have a lively discussion.

 

Beginning a new position at MIT as a Postdoctoral associate

Quick update and thank you to Professor Hart for continuing our work together and taking me on as a postdoctoral associate for the next year.  I’m honored and looking forward to visiting Boston again.