Conference

AACR 2018 discussion on brain metastasis phenotyping using a blood brain barrier on a chip

The University of Michigan released a discussion between the press staff and Dr. Oliver discussing the blood brain barrier on a chip device developed with Professors Merajver and Takayama. The potential of this platform may aid in precision phenotyping of cancer cells both prior and after diagnosis of brain metastasis enabling tailoring of the therapeutics and treatment given to a patient.

Dr. Oliver at AACR 2018.

Dr. Oliver interviewed by BCRF at AACR 2018

We attended AACR 2018 this year in Chicago and had the opportunity to present our work during the poster session. I presented the most recent results in the development of our blood brain barrier on a chip system that we are using to parenthetically characterize different cancer cells and measure their impact on the blood brain barrier.

During the session I was fortunate to get to share our work with one of our sponsers the Breast Cancer Research Foundation (BCRF).

https://www.bcrf.org/blog/aacr-2018-highlights-novel-approaches-treating-brain-metastasis-metastatic-breast-cancer

Dr. Oliver speaking at AACR 2018.

Organ-on-a-chip: Blood brain niche (um-BBN) microfluidic device and algorithms to aid diagnosis of brain metastatic potential of breast cancer

C. Ryan Oliver et al. 2018 Keystone Symposium Organ on a Chip.

We presented work continued work on the blood brain barrier platform but were fortunate to get to learn from other experts in organ-on-a-chip systems. It was an honor to get to discuss the field and develop a roadmap for integrating academia, regulation and industry into the planning process for organ-on-a-chip systems so that they can solve real world problems.

Special thanks to our sponsors BCRF and the National institute of health.

Braint Mets Conference Presentation

I will be attending the Brain Mets 2017 Conference in Marseille, France October 6-7.  More information can be found at http://brain-mets.com/

If you are there I look forward to meeting you.  Abstract below:

Development of a blood brain niche microfluidic device and algorithms to aid diagnosis of brain metastatic potential

Brain metastasis is the most lethal complication from advanced cancer.  15% of breast cancers metastasize in the brain with a low one-year survival rate.  A critical step in reducing the lethality of brain metastasis is early detection of clones with high metastatic potential.  Models for characterizing metastatic potential include murine models and […]

Progress towards blood brain barrier chip to be presented at AACR 2017

We will be attending the annual AACR (American Association for Cancer Research) meeting in D.C. April 1-5 to present our progress towards an organ on a chip model to study breast cancer metastasis in the brain.

This work provides an important foundation to apply microfluidics in translational identification of breast cancer clones that may contribute to aggressive brain metastasis.  Please join us and I look forward to meeting you.

MRS 2016: Template-Free Photoanchoring of Micro-Scale Objects for Manufacturing of Ultra-Miniature Electronic Devices

We will be presenting work on a new approach to scaling down assembly of micro-electronic components on flexible substrates at the Materials Research Society (MRS) conference in Boston.
It would be a pleasure to talk with you if you attend.

9:45 AM – BM4.5.05
Template-Free Photoanchoring of Micro-Scale Objects for Manufacturing of Ultra-Miniature Electronic Devices
C. Ryan Oliver , Lillian Chin , David Dellal , Nathan Spielberg , John Lewandowski , A. John Hart

The availability of higher performance microprocessors, communication chips, and inertial sensors with ever smaller dimensions has driven the miniaturization of passive IC components as well as the development of high-throughput surface mount assembly technology. Currently, circuit […]

Progress towards metastasis chip to be presented at AACR April 16-20

We will be attending the annual AACR (American Association for Cancer Research) meeting in New Orleans to present our progress towards an organ on a chip model to study breast cancer metastasis in the brain.

This work is being presented by Megan Altemus and was originally lead by Brendan Leung.  I hope to see you there or send me a message and I’ll be happy to discuss what we are working on.

 

 

Discrete Object Additive Manufacturing (DOAM): Digital Three-Dimensional Printing of Cells and Microbeads within Hydrogel Matrices

At the Materials Research Society (MRS) annual meeting (2015) I will be presenting my work titled: Discrete Object Additive Manufacturing (DOAM): Digital Three-Dimensional Printing of Cells and Microbeads within Hydrogel Matrices  

Authors: C. R. Oliver, A. J. Hart,

Symposium: C3.09

Location: Hynes Level 3, Room 305

Time: Dec 1 (Tuesday): 11:30 AM to 11:45 AM

 

I hope to see you there and have a lively discussion.

 

Scalable Fabrication of Stimuli-Responsive Liquid Crystalline Polymer Microstructures by Replica Molding

At the Materials Research Society (MRS) annual meeting (2015) Hangbo Zhao will be presenting our work titled:  Scalable Fabrication of Stimuli-Responsive Liquid Crystalline Polymer Microstructures by Replica Molding.

Authors: Hangbo Zhao, Jeong Jae Wie, Davor Copic, C. Ryan Oliver, Alvin W. Orbaek, Sanha Kim, and A. John Hart

Presentation: Oral

Symposium: Y. Shape Programmable Materials  

Location: Hynes, Level 1, Room 105

Time: December 1, 2015 (Tuesday)  2:15-2:30 pm

 

I hope to see you there and have a lively discussion.

Join us at the 2015 C. elegans International Conference

Eleni Gourgou and I will be presenting “Real-time behavioral study of C. elegans by dynamic in situ photopatterning of hydrogel assays” at the 2015 C. elegans International Conference.  Hope to see you there June 24-28.

http://www.genetics-gsa.org/celegans/2015/

Abstract:

Real-time behavioral study of C. elegans by dynamic in situ photopatterning of hydrogel assays

Eleni Gourgou1, 2*, C. Ryan Oliver1, 3*, Daphne Bazopoulou1, Nikos Chronis1, 4, A. John Hart3

1Mechanical Engineering, University of Michigan, Ann Arbor, MI

2Internal Medicine, Division of Geriatrics, Medical School, University of Michigan, Ann Arbor, MI

3Mechanical Engineering and Laboratory for Manufacturing and Productivity, Massachusetts Institute of Technology, Cambridge, MA

4Biomedical Engineering, University of Michigan, Ann Arbor, MI

*Equal […]